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Mol. Cells 2009; 28(2): 81-85
Published online August 20, 2009
https://doi.org/10.1007/s10059-009-0115-y
© The Korean Society for Molecular and Cellular Biology
Modeling the Cardiac Na+/H+ Exchanger Based on Major Experimental Findings
Na+-H+ exchanger (NHE) is the main acid extruder in car-diac myocytes. We review the experimental findings of ion-dependency of NHE activity, and the mathematical modeling developed so far. In spite of extensive investigation, many unsolved questions still remain. We consider that the precise description of NHE activity with mathematical models elucidates the roles of NHE in maintaining ionic homeostasis, especially under pathophysiological conditions.
Keywords ion dependency, mathematical model, NHE
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Mol. Cells 2009; 28(2): 81-85
Published online August 31, 2009 https://doi.org/10.1007/s10059-009-0115-y
Copyright © The Korean Society for Molecular and Cellular Biology.
Modeling the Cardiac Na+/H+ Exchanger Based on Major Experimental Findings
Chae Young Cha, and Akinori Noma
Abstract
Na+-H+ exchanger (NHE) is the main acid extruder in car-diac myocytes. We review the experimental findings of ion-dependency of NHE activity, and the mathematical modeling developed so far. In spite of extensive investigation, many unsolved questions still remain. We consider that the precise description of NHE activity with mathematical models elucidates the roles of NHE in maintaining ionic homeostasis, especially under pathophysiological conditions.
Keywords: ion dependency, mathematical model, NHE
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