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Mol. Cells 2009; 28(1): 7-12

Published online July 31, 2009

https://doi.org/10.1007/s10059-009-0111-2

© The Korean Society for Molecular and Cellular Biology

Biology of Glioma Cancer Stem Cells

Deric M. Park, and Jeremy N. Rich

Received: July 6, 2009; Accepted: July 9, 2009

Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

Keywords brain tumor, cancer stem cell, glioma, glioblastoma

Article

Minireview

Mol. Cells 2009; 28(1): 7-12

Published online July 31, 2009 https://doi.org/10.1007/s10059-009-0111-2

Copyright © The Korean Society for Molecular and Cellular Biology.

Biology of Glioma Cancer Stem Cells

Deric M. Park, and Jeremy N. Rich

Received: July 6, 2009; Accepted: July 9, 2009

Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

Keywords: brain tumor, cancer stem cell, glioma, glioblastoma

Mol. Cells
Sep 30, 2022 Vol.45 No.9, pp. 603~672
COVER PICTURE
The Target of Rapamycin Complex (TORC) is a central regulatory hub in eukaryotes, which is well conserved in diverse plant species, including tomato (Solanum lycopersicum). Inhibition of TORC genes (SlTOR, SlLST8, and SlRAPTOR) by VIGS (virus-induced gene silencing) results in early fruit ripening in tomato. The red/ orange tomatoes are early-ripened TORC-silenced fruits, while the green tomato is a control fruit. Top, left, control fruit (TRV2-myc); top, right, TRV2-SlLST8; bottom, left, TRV2-SlTOR; bottom, right, TRV2-SlRAPTOR(Choi et al., pp. 660-672).

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