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Mol. Cells 2009; 28(1): 1-5

Published online July 31, 2009

https://doi.org/10.1007/s10059-009-0109-9

© The Korean Society for Molecular and Cellular Biology

Protein Kinase D1, a New Molecular Player in VEGF Signaling and Angiogenesis

Chang Hoon Ha, and Zheng Gen Jin

Received: June 26, 2009; Accepted: June 29, 2009

Abstract

Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angi-ogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.

Keywords angiogenesis, CAMK, endothelial cells, HDAC, MEF2, migration, PKC, PKD, VEGF

Article

Minireview

Mol. Cells 2009; 28(1): 1-5

Published online July 31, 2009 https://doi.org/10.1007/s10059-009-0109-9

Copyright © The Korean Society for Molecular and Cellular Biology.

Protein Kinase D1, a New Molecular Player in VEGF Signaling and Angiogenesis

Chang Hoon Ha, and Zheng Gen Jin

Received: June 26, 2009; Accepted: June 29, 2009

Abstract

Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angi-ogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.

Keywords: angiogenesis, CAMK, endothelial cells, HDAC, MEF2, migration, PKC, PKD, VEGF

Mol. Cells
Nov 30, 2022 Vol.45 No.11, pp. 763~867
COVER PICTURE
Naive (cyan) and axotomized (magenta) retinal ganglion cell axons in Xenopus tropicalis (Choi et al., pp. 846-854).

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