Mol. Cells 2009; 28(1): 1-5
Published online July 20, 2009
https://doi.org/10.1007/s10059-009-0109-9
© The Korean Society for Molecular and Cellular Biology
Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angi-ogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.
Keywords angiogenesis, CAMK, endothelial cells, HDAC, MEF2, migration, PKC, PKD, VEGF
Mol. Cells 2009; 28(1): 1-5
Published online July 31, 2009 https://doi.org/10.1007/s10059-009-0109-9
Copyright © The Korean Society for Molecular and Cellular Biology.
Chang Hoon Ha, and Zheng Gen Jin
Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angi-ogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.
Keywords: angiogenesis, CAMK, endothelial cells, HDAC, MEF2, migration, PKC, PKD, VEGF
Da-Hye Lee, Jungsul Lee, Jongwook Jeon, Kyung-Jin Kim, Jang-Hyuk Yun, Han-Seok Jeong, Eun Hui Lee, Young Jun Koh, and Chung-Hyun Cho
Mol. Cells 2018; 41(8): 771-780 https://doi.org/10.14348/molcells.2018.0207Yong Jiang, He Liu, Wen-jing Liu, Hai-bin Tong, Chang-jun Chen, Fu-gui Lin, Yan-hang Zhuo, Xiao-zhen Qian, Zeng-bin Wang, Yu Wang, Peng Zhang, and Hong-liang Jia
Mol. Cells 2016; 39(4): 292-298 https://doi.org/10.14348/molcells.2016.2223Hee Kyoung Joo, Yu Ran Lee, Gun Kang, Sunga Choi, Cuk-Seong Kim, Sungwoo Ryoo, Jin Bong Park, and Byeong Hwa Jeon
Mol. Cells 2015; 38(12): 1064-1070 https://doi.org/10.14348/molcells.2015.0165