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Mol. Cells 2009; 27(5): 571-575

Published online May 15, 2009

https://doi.org/10.1007/s10059-009-0075-2

© The Korean Society for Molecular and Cellular Biology

ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

Myounghee Chae, Gyu-Seek Rhee, Ik-Soon Jang, Kwangsoo Kim, Ji-Hae Lee, Seung-Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, and Seung-Hoon Lee

Received: February 2, 2009; Revised: March 13, 2009; Accepted: March 23, 2009

Abstract

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The amphetamine derivative 3, 4-methylenedioxymetham- phetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblas-toma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Keywords Atg5, autophagy, MDMA, neuron, PC12, SH-SY5Y

Article

Research Article

Mol. Cells 2009; 27(5): 571-575

Published online May 31, 2009 https://doi.org/10.1007/s10059-009-0075-2

Copyright © The Korean Society for Molecular and Cellular Biology.

ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

Myounghee Chae, Gyu-Seek Rhee, Ik-Soon Jang, Kwangsoo Kim, Ji-Hae Lee, Seung-Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, and Seung-Hoon Lee

Received: February 2, 2009; Revised: March 13, 2009; Accepted: March 23, 2009

Abstract

The amphetamine derivative 3, 4-methylenedioxymetham- phetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblas-toma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Keywords: Atg5, autophagy, MDMA, neuron, PC12, SH-SY5Y

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.
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