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Mol. Cells 2009; 27(5): 503-513

Published online May 15, 2009

https://doi.org/10.1007/s10059-009-0069-0

© The Korean Society for Molecular and Cellular Biology

Basement Membrane Proteoglycans: Modulators Par Excellence of Cancer Growth and Angiogenesis

Renato V. Iozzo, Jason J. Zoeller, and Alexander Nystroem

Received: April 22, 2009; Accepted: April 25, 2009

Abstract

Proteoglycans located in basement membranes, the nanos-tructures underling epithelial and endothelial lay-ers, are unique in several respects. They are usually large, elon-gated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these contribute not only to storing and preserving the biological activity of various heparan sulfate-binding cytokines and growth factors, but also in presenting them in a more “active configuration” to their cognate receptors. Abnormal expression or deregulated function of these proteoglycans affect cancer and angiogenesis, and are critical for the evolution of the tumor microenvironment. This review will focus on the func-tional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.

Keywords agrin, angiogenesis, cancer, collagen XVIII, endorepellin, endostatin, heparan sulfate proteoglycans, perlecan

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Mol. Cells 2009; 27(5): 503-513

Published online May 31, 2009 https://doi.org/10.1007/s10059-009-0069-0

Copyright © The Korean Society for Molecular and Cellular Biology.

Basement Membrane Proteoglycans: Modulators Par Excellence of Cancer Growth and Angiogenesis

Renato V. Iozzo, Jason J. Zoeller, and Alexander Nystroem

Received: April 22, 2009; Accepted: April 25, 2009

Abstract

Proteoglycans located in basement membranes, the nanos-tructures underling epithelial and endothelial lay-ers, are unique in several respects. They are usually large, elon-gated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these contribute not only to storing and preserving the biological activity of various heparan sulfate-binding cytokines and growth factors, but also in presenting them in a more “active configuration” to their cognate receptors. Abnormal expression or deregulated function of these proteoglycans affect cancer and angiogenesis, and are critical for the evolution of the tumor microenvironment. This review will focus on the func-tional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.

Keywords: agrin, angiogenesis, cancer, collagen XVIII, endorepellin, endostatin, heparan sulfate proteoglycans, perlecan

Mol. Cells
Feb 28, 2023 Vol.46 No.2, pp. 69~129
COVER PICTURE
The bulk tissue is a heterogeneous mixture of various cell types, which is depicted as a skein of intertwined threads with diverse colors each of which represents a unique cell type. Single-cell omics analysis untangles efficiently the skein according to the color by providing information of molecules at individual cells and interpretation of such information based on different cell types. The molecules that can be profiled at the individual cell by single-cell omics analysis includes DNA (bottom middle), RNA (bottom right), and protein (bottom left). This special issue reviews single-cell technologies and computational methods that have been developed for the single-cell omics analysis and how they have been applied to improve our understanding of the underlying mechanisms of biological and pathological phenomena at the single-cell level.

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