Mol. Cells 2001; 12(3): 368-371
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Epithelial cells within the mammary gland undergo apoptosis during weaning. To determine the expression of Bok mRNA (a member of the pro-apoptotic Bcl-2 family) in the mammary gland and its regulation, we examined the expression of the Bok transcript in the mouse mammary gland and HC11 mammary epithe-lial cells in culture through RT-PCR. The Bok mRNA expression was found in the mammary gland. The ex-pression of the Bok mRNA level was induced through serum starvation and overexpression of Bok induced apoptosis in HC11 cells in culture. These results indi-cate that the expression of Bok mRNA in the mam-mary gland is regulated through serum starvation. It also may be related to the mammary involution.
Keywords Bok, Ser, Apoptosis, HC11 Mammary Epithelial Cells
Mol. Cells 2001; 12(3): 368-371
Published online December 31, 2001
Copyright © The Korean Society for Molecular and Cellular Biology.
Seck-Ho Ha, Sul-Ra Lee, Tae-Hoon Lee, Young-Min Kim, Myung-Gi Baik, Yun-Jaie Choi
Epithelial cells within the mammary gland undergo apoptosis during weaning. To determine the expression of Bok mRNA (a member of the pro-apoptotic Bcl-2 family) in the mammary gland and its regulation, we examined the expression of the Bok transcript in the mouse mammary gland and HC11 mammary epithe-lial cells in culture through RT-PCR. The Bok mRNA expression was found in the mammary gland. The ex-pression of the Bok mRNA level was induced through serum starvation and overexpression of Bok induced apoptosis in HC11 cells in culture. These results indi-cate that the expression of Bok mRNA in the mam-mary gland is regulated through serum starvation. It also may be related to the mammary involution.
Keywords: Bok, Ser, Apoptosis, HC11 Mammary Epithelial Cells
Youngleem Kim, Dai-Wu Seol
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