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Mol. Cells 2001; 12(3): 368-371
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
The Expression of Bok Is Regulated by Serum in HC11 Mammary Epithelial Cells
Epithelial cells within the mammary gland undergo apoptosis during weaning. To determine the expression of Bok mRNA (a member of the pro-apoptotic Bcl-2 family) in the mammary gland and its regulation, we examined the expression of the Bok transcript in the mouse mammary gland and HC11 mammary epithe-lial cells in culture through RT-PCR. The Bok mRNA expression was found in the mammary gland. The ex-pression of the Bok mRNA level was induced through serum starvation and overexpression of Bok induced apoptosis in HC11 cells in culture. These results indi-cate that the expression of Bok mRNA in the mam-mary gland is regulated through serum starvation. It also may be related to the mammary involution.
Keywords Bok, Ser, Apoptosis, HC11 Mammary Epithelial Cells
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Research Article
Mol. Cells 2001; 12(3): 368-371
Published online December 31, 2001
Copyright © The Korean Society for Molecular and Cellular Biology.
The Expression of Bok Is Regulated by Serum in HC11 Mammary Epithelial Cells
Seck-Ho Ha, Sul-Ra Lee, Tae-Hoon Lee, Young-Min Kim, Myung-Gi Baik, Yun-Jaie Choi
Abstract
Epithelial cells within the mammary gland undergo apoptosis during weaning. To determine the expression of Bok mRNA (a member of the pro-apoptotic Bcl-2 family) in the mammary gland and its regulation, we examined the expression of the Bok transcript in the mouse mammary gland and HC11 mammary epithe-lial cells in culture through RT-PCR. The Bok mRNA expression was found in the mammary gland. The ex-pression of the Bok mRNA level was induced through serum starvation and overexpression of Bok induced apoptosis in HC11 cells in culture. These results indi-cate that the expression of Bok mRNA in the mam-mary gland is regulated through serum starvation. It also may be related to the mammary involution.
Keywords: Bok, Ser, Apoptosis, HC11 Mammary Epithelial Cells
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