Mol. Cells 2023; 46(4): 206-208
Published online March 22, 2023
https://doi.org/10.14348/molcells.2023.0027
© The Korean Society for Molecular and Cellular Biology
Correspondence to : jwsohn@kaist.ac.kr
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
The brain serotonin system regulates several physiological functions such as mood, sleep, and food intake by binding to their cognate receptors (Jonnakuty and Gragnoli, 2008). Particularly, the serotonin 2C receptor (
Recently, the Farooqi and Xu laboratories identified 13 rare variants of
To further examine whether the F327L
Given the role of serotonin in coordinating the defensive behaviors in response to threats (Haller et al., 2005), the authors performed several behavioral assessments. In the resident–intruder tests, the “resident”
The World Health Organization declared obesity as a disease because of its prevalence and comorbidities such as type 2 diabetes, hypertension, and dyslipidemia (James, 2008). Obesity associated with mutations of a few genes such as those coding for leptin (
This work was supported by a grant from the National Research Foundation of Korea (2022R1A2C3005613 to J.-W.S.).
E.-S.Y. and J.-W.S. reviewed the literature and wrote the manuscript.
The authors have no potential conflicts of interest to disclose.
Mol. Cells 2023; 46(4): 206-208
Published online April 30, 2023 https://doi.org/10.14348/molcells.2023.0027
Copyright © The Korean Society for Molecular and Cellular Biology.
Htr2c variants in human obesity
Eun-Seon Yoo and Jong-Woo Sohn
*
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
Correspondence to:jwsohn@kaist.ac.kr
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
The brain serotonin system regulates several physiological functions such as mood, sleep, and food intake by binding to their cognate receptors (Jonnakuty and Gragnoli, 2008). Particularly, the serotonin 2C receptor (
Recently, the Farooqi and Xu laboratories identified 13 rare variants of
To further examine whether the F327L
Given the role of serotonin in coordinating the defensive behaviors in response to threats (Haller et al., 2005), the authors performed several behavioral assessments. In the resident–intruder tests, the “resident”
The World Health Organization declared obesity as a disease because of its prevalence and comorbidities such as type 2 diabetes, hypertension, and dyslipidemia (James, 2008). Obesity associated with mutations of a few genes such as those coding for leptin (
This work was supported by a grant from the National Research Foundation of Korea (2022R1A2C3005613 to J.-W.S.).
E.-S.Y. and J.-W.S. reviewed the literature and wrote the manuscript.
The authors have no potential conflicts of interest to disclose.