The conserved Ca2+/calmodulin-dependent phosphatase calcineurin has been shown to be involved in numerous and diverse functions both at the cellular and organism level. Recent genetic and pharmacological studies in animals including C. elegans, Drosophila, Aplysia, rat and mice have also implicated calcineurin in behavior, particularly in the regulation of plasticity and modulation of behaviors. These studies have not only brought a clearer understanding of the molecular contributions to behavior, but should also give insight into roles that calcineurin may be playing in the cognitive and behavioral defects observed in some diseases.

Keywords: Aplysia, C. elegans, Drosophila, Mice