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Fig. 5. Effect of tumour-derived Reg3A-educated DCs on the growth of BxPC-3 tumour xenografts and the percentage of human CD4+ and CD8+ T cells in human immune reconstituted SCID mice. (A) Tumour volume was determined once a week by measuring the minimum width (a) and ribbon width (b) of the tumour and calculated by the formula V = ab2/2. (B) Images of dissected tumours from mice transferred BxPC-3control (upper) and BxPC-3REG3A high (lower) cells. (C) Tumour weights. (D and E) Percentages of cells positive for human CD4+ and CD8+ T cells in peripheral blood samples. n = 3, *P < 0.05, compared with the mice transferred BxPC-3Control cells. Data represent three independent experiments.
Mol. Cells 2021;44:647~657
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