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Fig. 2. Effect of tumour-derived Reg3A on the function of DCs.
(A) Uptake of FITC-dextran by DCs was measured by flow cytometry. Red line: The endocytic function of DCs co-cultured with Reg3A-overexpressing/silenced PC cells. Grey line: The endocytic function of DCs co-cultured with PC cells transfected with mock vector. (B) The ability of DCs to induce T lymphocyte proliferation was assessed by measuring the absorbance at 450 nm, which was normalized to that of the Con A‐positive control producing a ratio. n = 3, *P < 0.05, **P < 0.01, compared with the corresponding control group. Data represent three independent experiments.
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