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Fig. 1. C. elegans avoids toxic bacteria better by detecting blue color.
P. aeruginosa, a pathogenic bacterium, synthesizes pyocyanin, a blue toxin that generates reactive oxygen species (ROS). C. elegans avoids blue color with ROS. JKK-1 (c-Jun N-terminal kinase kinase 1) and LEC-3 (galectin-3), which are cellular stress response proteins, mediate the blue color-dependent avoidance of wild-type C. elegans. This color detection system of C. elegans may help avoid pathogens and enhance its survival in nature.
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