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Fig. 4. The therapeutic effect of repeated intratracheal treatment of hUC-MSCs in the development of HDM/DEP-induced severe asthma. Mice were induced to develop HDM/DEP-induced asthma and were then injected intratracheally (i.t.) with hUC-MSCs on day 0 and/or 7. (A) Schematic depiction of the treatment protocol. (B and C) Measurement of AHR (B) and BAL cell counts (C) after treatment. (D and E) IL-5 and IL-13 production of Th2 cells (D) and ILC2 (F) in the lung after treatment. The data shown represent 3 independent experiments (n = 3~4 for each group). The data are expressed as mean ± SEM. Groups were compared by one-way (D and E) or two-way (B and C) ANOVA with Dunnett’s post-hoc test. *P ˂ 0.05; **P ˂ 0.01; ***P ˂ 0.001. CTRL, control; AM, alveolar macrophages; Eos, eosinophils; Neu, neutrophils; Lympho, lymphocytes.
Mol. Cells 2021;44:580~590
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