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Fig. 3. Reduction of lung type 2 cytokine production in A. alternata-induced asthma by intratracheal hUC-MSC treatment during the induction period. Mice were induced to develop A. alternata-induced asthma and were then injected intratracheally (i.t.) with hUC-MSCs on day 0 or 3. (A) Schematic depiction of the treatment protocol. (B and C) Measurement of AHR (B) and BAL cell counts (C) after treatment. (D and E) IL-5 and IL-13 production of Th2 cells (D) and ILC2s (E) in the lung after treatment. The data shown represent 3 independent experiments (n = 4 for each group). The data are expressed as mean ± SEM. Groups were compared by one-way (D and E) or two-way (B and C) ANOVA with Dunnett’s post-hoc test. *P ˂ 0.05; ***P ˂ 0.001; n.s., not significant. CTRL, control; AM, alveolar macrophages; Eos, eosinophils; Neu, neutrophils; Lympho, lymphocytes.
Mol. Cells 2021;44:580~590
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