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Fig. 1. Association between the route of hUC-MSC administration with the baseline lung lymphocyte profiles. Naïve mice were treated intravenously (i.v.) or intratracheally (i.t.) with hUC-MSCs. (A) Schematic depiction of the treatment regimen. (B) Counts of the indicated cells in the BAL fluid after treatment. (C and D) IL-5 and IL-13 production of the Th2 cells (C) and ILC2s (D) in the lung after hUC-MSC treatment. The data shown represent 3 independent experiments (n = 4 for each group). The data are expressed as mean ± SEM. Groups were compared by one-way (C and D) or two-way (B) ANOVA with Dunnett’s post-hoc test. *P ˂ 0.05; **P ˂ 0.01; ***P ˂ 0.001; n.s., not significant. AM, alveolar macrophages; Eos, eosinophils; Neu, neutrophils; Lympho, lymphocytes; CTRL, control.
Mol. Cells 2021;44:580~590
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