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Fig. 2. Deletion of Kcnma1 impairs bone formation in mice
. (A) Body weight was recorded every week beginning one month after the mice were born. Osterix-Cre(+); Kcnma1f/f mice were used as the control. (B) The length of the tibiae was measured in 4-month-old mice, n = 5. (C) Decreased length of tibiae of Osterix-Cre(+); Kcnma1f/f mice compared to control littermates. (D) Representative micro-CT images of trabecular and cortical bone in the tibiae of female mice at 4 months of age are shown. (E) Micro-CT measurements for Tb.BMD, Tb.Th, Tb.Sp, Ct.BMD, Ct.Th, and BV/TV from the groups of mice indicated, n ≥ 4. (F) H&E staining of the tibiae of Osterix-Cre(–); Kcnma1f/f and Osterix-Cre(+); Kcnma1f/f mice. Scale bars = 200 μm. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.
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