Molecules and Cells

Download original image

Fig. 3. ISNb motor axon guidance phenotypes in wild-type and mutant embryos. (A) In wild-type embryos, highly stereotyped projection patterns of ISNb motor axons are observed. Abdominal muscles are represented by numbers. (B) Fusion bypass phenotype is frequently found in embryos overexpressing FasII and genetically muscle-ablated embryos. This phenotype is also observed in many different types of mutant embryos, such as Sema-1a, PlexA, Dptp69D Dptp99A, and side. (C) Parallel bypass phenotype is often detected in embryos homozygous for either Dlar or beat-1a. (D) Stall phenotype is the most frequently observed defect in Sema-1a homozygous mutants. Similar but milder stall phenotype is found in embryos homozygous for PlexA. (E) U-turn phenotype is clearly observed in Dptp69D Dptp99A homozygotes. (F) In split/detour phenotype of Dptp69D Dptp99A mutants, some ISNb axons segregate from the ISN at an abnormal choice point and innervate muscles 13 and 12.
Mol. Cells 2021;44:549~556
© Mol. Cells
© The Korean Society for Molecular and Cellular Biology. Powered by INFOrang Co., Ltd