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Fig. 1. Immune suppressive and immune stimulatory cell-favored niche. The immune suppressive environment (left) shows the 1) immune suppressive cells including Tregs and MDSCs, 2) the expression of immune suppressive cytokines, and 3) upregulation of immune checkpoint receptors such as TIGIT, LAG-3, and TIM-3 by T cells. The immune stimulatory environment includes PD-1 expression by T cells (right). The immune suppressive cell-favored niche does not respond well to ICIs, while the immune stimulatory responds favorably to ICIs.
Mol. Cells 2021;44:363~373
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