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Fig. 2. Overview of antigen presentation by CD1a and roles of CD1a-reactive T cells in diseases.
CD1a-expressing APCs are abundant, but not limited, in skin. Antigens of CD1a are derived from self or various foreign sources such as Mycobacteria, plants and cosmetics, and presented on CD1a in early/recycling endosomal compartments or at cell surface. Similar to the origins of antigens, host- or foreign-derived PLA2 can generate neoantigens of CD1a under certain conditions. CD1a-reactive T cells activated by recognizing the complex of CD1a and antigen or CD1a itself produce various cytokines, thereby controlling immune responses occurred in inflammatory skin diseases such as contact dermatitis, psoriasis and atopic dermatitis.
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