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Fig. 1. Fine-tuning of GM-CSFR signaling in AMs. Upon binding of GM-CSF to the GM-CSFR, the GM-CSFR βc is phosphorylated, which initiates downstream signaling. GM-CSFR signaling triggers the rapid upregulation of the phosphatase Ssu72, which directly binds to and dephosphorylates the GM-CSFR βc. This fine-tuning mechanism for GM-CSFR signaling is critical for the PPAR-γ, as well as mitochondrial respiration and cytokine secretion, in AMs.
Mol. Cells 2021;44:292~300
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