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Fig. 2. Dynamic binding of p27 to Cdk2/cyclin A in the cell cycle regulation. A schematic illustration is shown for the sequential steps of the activation of Cdk2/cyclin A driving progression from G1 to S phase of the cell division cycle. Conformational fluctuations of the subdomains of p27 (D2 and 310) are indicated by the double-sided arrows. See the text for the detailed discussion.
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