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Fig. 1. Inflammatory AT and TME synergistically communicate to favor the growth of cancer cells. Commonalities between propagating adipocytes and cancer cells reshaping ECM constituents and stiffness are illustrated above. The interplay between adipocytes and TME integrates multiple factors. Fibroblasts from both inflammatory AT and TME induce fibrosis which reorganizes ECM compartments. IL-6 secreted from cancer cells causes adipocyte dedifferentiation and delipidation to supply FFA to tumor cells. MCP-1 and CXCL12 cooperatively mediate macrophage infiltration into both AT and TME, where M1 and M2 polarization can be alternatively converted depending on the environmental conditions. Vascularization fulfills oxygen and nutritional demands for both adipocytes and cancer cells.
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