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Fig. 1. Diverse approaches to associate spatial information with transcriptomics. (A) Cryosection provides positional information. (B) LCM provides fine resolution (even to single cell) positional information. (C) Image-based single cell level spatial transcriptomic approaches. osmFISH labels RNA with a number of colors each time for different genes. seqFish uses a combination of colors to mark RNAs. MERFISH labels presence or absence of fluorescence. (D) Spatial transcriptomics uses barcodes to spatially distinguish each spot. (E) RNAseq for interacting cells provides relative spatial information. (F) Spatial reconstruction uses transcriptomic information to reconstruct original spatial information.
Mol. Cells 2020;43:591~599
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