Molecules and Cells

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Fig. 2. Deubiquitinating enzymes involved in the regulation of nervous system and neurological disorders. (A) USP9X is associated with microtubule-associated protein DCX and USP33 regulates axonal guidance receptor Robo1 and Slit 1/2 pathway. (B) USP9X, USP12, USP13, Ataxin-3, and UCH-L1 are directly or indirectly involved in the regulation of various neurodegenerative disorders. (C) USP8 interacts with synaptic protein SHANK3, USP14 stabilizes GABAARs to regulate NMJ & muscle development, USP46 regulates AMPARs to modulate the synaptic plasticity and UCH-L1 is involved in regulation of synaptic development, synaptic function, synaptic plasticity and synaptic transmission. (D) USP18 causes microglial quiescence and regulates IFN signaling via Stat 1. (E) USP4, USP7, USP9X, USP13, USP22, USP39, and USP48 are highly expressed in human gliomas and regulates cell survival. USP17 expression is low in gliomas and reduces tumorigenesis. (F) USP36 regulates Nedd 4-2, an E3 ligase of TrKA, involved in axonal growth and survival, whereas USP4 regulates GPCR and stabilizes TRAF6 in NF-κB pathway. CYLD is involved in the regulation of neuro-inflammation via NF-κB pathway.
Mol. Cells 2020;43:203~214 https://doi.org/10.14348/molcells.2020.2289
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