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Fig. 1. The ubiquitin proteasome system. (A) Ubiquitination is catalyzed by organized events mediated by E1, E2, and E3 ligases which promote the ligation of ubiquitin molecule to the lysine residues in the target protein substrates. Ubiquitin(s) attached proteins undergo the 26s proteasome degradation. (B) Deubiquitinating enzyme can remove the poly-, multi-, mono-ubiquitin molecules attached to the target substrate and inhibits its degradation and thereby stabilizes it.
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