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Fig. 1. p53 status as a contextual determinant of the duality of RUNX3. Following DNA damage or oncogenic stress, RUNX3 positively regulates p53 and is in turn suppressed by it; p53 then prevents tumorigenesis by decreasing the activity of crucial oncogenes such as MYC (left). Upon inactivation of p53, dysregulated RUNX3 starts to aberrantly upregulate MYC (right). Thus, p53 status is a contextual determinant for whether RUNX3 behaves as a tumor-suppressor or oncogene.
Mol. Cells 2020;43:176~181 https://doi.org/10.14348/molcells.2019.0285
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