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Fig. 2. Regulation of RUNX2 stability and transcriptional activity at post-translational levels. Upon the activation of FGF/FGFR-Erk MAPK signaling pathway, RUNX2 is stabilized and transactivated by multiple post-translational modification cascades: phosphorylation by Erk MAPK, prolyl isomerization by Pin1, acetylation by HAT. Phosphorylation of RUNX2 by GSK3β and cyclin D1/CDK4 induces ubiquitin-proteasomal degradation of RUNX2. BMP/BMPR stimulates p300-mediated RUNX2 acetylation by protecting RUNX2 from Smurf1-mediated degradation.
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