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Fig. 3. Co-mutations of RUNX1 and NF1 contribute to blood malignancy. RUNX1 t(8;21) translocation (RUNX1-ETO) represses NF1 to develop AML. RUNX1 mutation or NF1/RAS-RUNX1 co-mutation develop AML or MDS through clonal selection and cell proliferation.
Mol. Cells 2020;43:153~159 https://doi.org/10.14348/molcells.2019.0295
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