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Fig. 2. NF1 and RUNX1 are both drivers of several solid tumor formation. NF1 serves as a tumor suppressor to contribute to breast cancer, lung cancer, glioblastoma multiform and several other tumor formation. RUNX1 functions as a tumor suppressor or an oncogene to drive tumorigenesis in the context of specific tissues. NF1 and RUNX1 co-mutations might contribute to tumorigenesis on rare events in some cancers.
Mol. Cells 2020;43:153~159
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