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Fig. 1. Loss of NF1 activates RUNX1 to drive neurofibromagenesis. Loss of NF1 elevates RAS-GTP to active downstream MEK/ERK signaling, which in turn phosphorylates RUNX1. Activated RUNX1 drives neurofibromagenesis by inhibiting PMP22, p53/p21 or other unknown gene(s)/pathway(s).
Mol. Cells 2020;43:153~159 https://doi.org/10.14348/molcells.2019.0295
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