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Fig. 1. Model of leukemic progression in mice based on serial transplantation of Csf3r-d715/RUNX1-RHD mutant BM cells. In primary recipients, the combination of Csf3r-d715 and RUNX1-D171N gives rise to accumulation of immature LK cells. This occurs only when mice are treated with G-CSF (CSF3) and mice do not succumb to symptoms of leukemia. Upon secondary and subsequent transplantations of these LK cells, a G-CSF independent AML develops, which is characterized by elevated inflammatory responses and reduced TET2 protein levels.
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