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Fig. 1. (A) Pathways targeted by currently available senolytic and senostatic drugs. (B) Human diseases have been shown to be delayed by senotherapy (modified from ). EFNB1, ephrin B1; GF, growth factor; PI3K, phosphoinositide 3-kinases; MDM2, mouse double minute 2 homolog; Bcl2, B-cell lymphoma 2; Mcl-1, myeloid cell leukemia 1; Bcl-xL, B-cell lymphoma-extra large; FOXO4, forkhead Box O4; D + Q, co-treatment of dasatinib and quercetin.
Mol. Cells 2019;42:821~827
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