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Fig. 2. In this model, DSK2B is proposed to serve as a shuttle factor for proteasomal degradation of BES1 in the nucleus. During starvation or drought stress, the autophagy adaptor DSK2A targets ubiquitylated BES1 for vacuolar degradation. Starvation-induced autophagy typically shows little selectivity (i), whereas the possibility of selective autophagy cannot be excluded (ii). For example, ubquitylated BES1 may be concentrated in a cytoplasmic reservoir, which can be selectively delivered to the vacuole. Dashed arrows indicate hypothetical points in nuclear and cytoplasmic pathways, both of which use ubiquitins (grey stars) as a destruction signal. In the cytoplasm, DSK2A/B may mediate the degradation of BES1 by the proteasome (not shown).
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