Molecules and Cells

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Fig. 1. Yeast-specific ERMES is composed by a multiprotein complex including ER protein Mmm1, cytosolic protein Mdm12, as well as mitochondrial protein Mdm34 and Mdm10. In mammalian cells, the interface between ER and mitochondria contains MFN2-MFN1/2, BAP31-Fis1, IP3R-Grp75-VDAC, and PTPIP51-VAPB or −ORP5/8 tethering complexes, which makes the two organelles close juxtaposition. Other single proteins, such as PS2, PACS-2, Tespa1, SigR1 and MCU, are also associated in the ER-mitochondria tethering complexes.
Mol. Cells 2018;41:1000~1007
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