Download original image
Fig. 1. Yeast-specific ERMES is composed by a multiprotein complex including ER protein Mmm1, cytosolic protein Mdm12, as well as mitochondrial protein Mdm34 and Mdm10. In mammalian cells, the interface between ER and mitochondria contains MFN2-MFN1/2, BAP31-Fis1, IP3R-Grp75-VDAC, and PTPIP51-VAPB or −ORP5/8 tethering complexes, which makes the two organelles close juxtaposition. Other single proteins, such as PS2, PACS-2, Tespa1, SigR1 and MCU, are also associated in the ER-mitochondria tethering complexes.
© Mol. Cells