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Fig. 1. Gene-editing technologies can resolve three unmet medical needs of CAR-T cell therapy. First, gene-editing allows development of universal off-the-shelf CAR-T cells by alleviating GvH and HvG. Second, gene-editing broadens the range of otherwise untargetable CAR target antigens by preventing CAR-T cell fratricide of. Third, gene-editing enhances anti-tumor responses by circumventing T-cell hypofunction caused by continuous activation and immunosuppressive TME, which may expand the use of CAR-T cell therapy for solid tumors.
Mol. Cells 2018;41:717~723
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