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Fig. 2. E3 ubiquitin ligases, SIVA1, MKRN1 and ULF induces ubiquitination dependent pro-teasomal degradation of ARF, which is reversed by deubiquitinase, USP10-mediated deubiquitination. CHIP and HSP90 cooperatively stimulates ubiquitin-independent lysosomal degradation of ARF.
Mol. Cells 2018;41:381~389 https://doi.org/10.14348/molcells.2018.0100
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