Download original image
Fig. 2. The CM is specified by Wnt-βCtn signaling in the edge of the double-layered OC of the midgestation mouse embryo. In late embryonic mouse eyes, RPCs receive Shh signals from RGCs, in addition to self-maintaining Notch signals, and sustain their proliferation at a high rate. Lrp2 expressed in CM cells prevents Shh from activating their proliferation, maintaining a lower proliferation rate in CM cells than in RPCs. In the post-natal mouse eye, the CM starts to form folds that develop into the CB with the help of autocrine BMPs, which are indirectly activated by Notch signals.
© Mol. Cells