Molecules and Cells

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Fig. 1. The neuroepithelium in mouse embryonic ventral diencephalon evaginates laterally to form the optic vesicle (OV), which then invaginates to form double-layered optic cup by E12.5. The proliferation rate of neuroepithelium in the OV is highest in the distal part, which is specified into primitive neural retina (pNR) (left). In the optic cup of mouse embryonic eye, the proliferation rate is displayed more diversely. Post-mitotic RPE cells form a monolayer sheet, while RPCs in the NR actively proliferate to produce retinal neurons (middle). The CM is specified in the border between the NR and RPE, and the cells in the CM proliferate moderately. The CM area further develops to form the ciliary body (CB) in the post-natal eye. The cells in the outer layer of CM/CB are pigmented, whereas those in the inner CM/CB layer are non-pigmented. The ciliary epithelium (CE) comprising the CB proliferates in the post-natal days, when majority cells in the NR become post-mitotic (right), and this drives the growth of the eye.
Mol. Cells 2018;41:257~263
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