Molecules and Cells

Download original image

Fig. 3. The accumulation of misfolded proteins and their aggregates stimulates the cytosolic relocalization and N-terminal arginylation of ER-residing chaperones such as BiP, calreticulin, and protein disulfide isomerase. Cytosolic R-BiP is associated with cargoes and bind the ZZ domain of p62, facilitating p62 self-polymerization and interaction with LC3. In addition, the ligand-bound p62 induces autophagosome biogenesis. Through this dual regulation, cells can efficiently remove misfolded proteins in a real time basis.
Mol. Cells 2017;40:441~449
© Mol. Cells
© The Korean Society for Molecular and Cellular Biology. Powered by INFOrang Co., Ltd