Molecules and Cells

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Fig. 1. Cilia structure.

The scheme depicts the structure of a primary cilium. At their base eukaryotic cilia present a centriole/basal body, from which the axoneme microtubules elongate, and accessory structures such as the basal foot and the transition fibers. The ciliary membrane is a specialized membrane domain enriched in specific proteins (e.g. ARL13B) and lipid species (e.g. PI(4)P). At the proximal region of the axoneme is the transition zone characterized by microtubule-membrane connectors. Distal to the transition zone is localized the inversin domain which lacks y-links and has a distinct protein composition from the transition zone. The figure shows the protein modules present at the transition zone largely as they were described by Chih et al. (2011), Garcia-Gonzalo et al. (2011), and Sang et al. (2011). Indicated are also genetic interactions between components of the transition zone modules and components of the BBSome and IFT.

Mol. Cells 2017;40:243~253
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