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Fig. 3. (A) Transcription-coupled splicing in chromatin. Transcription elongation and splicing are regulated by Pol II phosphorylation, histone modification, and SR–protein interactions. More SR proteins (shown in different colors) are recruited, and spliceosome assembly occurs on nascent pre-mRNP. Storage and assembly of splicing machinery in speckles is also shown. (B) mRNA export from the nucleus to cytoplasm. Export receptor (NXF) is recruited to export adaptor SR-bound mRNA. (C) Translational regulation in the cytoplasm.
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