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Fig. 3. A proposed model to explain the effect of global and local competition between exo- and endo-miRNAs on the derepression of endo-miRNA targets. (A) mRNAs without exo- or endo-miRNA TSs on their 3′-UTRs are not affected by miRNA or siRNA transfection. (B) mRNAs with endo-miRNA TSs but no exo-miRNA TS show a moderate degree of derepression caused by the global competition between exo- and endo-miRNAs. (C) mRNAs with both exo- and endo-miRNA TSs show a strong derepression, resulting from both the global and local competition between exo- and endo-miRNAs.
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