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Fig. 2. The effect of the local competition between exo- and endo-miRNAs on derepression of endo-miRNA targets. (A) For mRNAs with a single exo-miRNA 8mer site, the correlation between mRNA fold-change and 3′-UTR length was analyzed (red). The same correlation analysis was repeated for 7mer-m8 (orange), 7mer-A1 (green), 6mer (blue), and no site (magenta). (B) mRNA fold-change values were correlated with log values of 3′-UTR length (thick lines) and their simple linear regression lines (thin lines) are shown together. Otherwise as in (A). (C) For each pair of mRNAs that have nearly identical 3′-UTR, one with a stronger proficiency (measured by the sum of context+ scores) of exo-miRNA 7?8mer sites was classified to be the “stronger exo-miRNA 7?8mer sites” group, while the other was classified as “weaker exo-miRNA 7?8mer sites” group. A pair of mRNAs with the smallest difference in their 3′-UTR length was iteratively chosen until the 3′-UTR length difference became longer than 50 nucleotides. For each of the “stronger exo-miRNA TSs” and “weaker exo-miRNA TSs” group, mRNA fold-change values were correlated with log values of 3′UTR length. Otherwise as in (B).
Mol. Cells 2014;37:412~417
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