Hak Kyun KimMol. Cells 2019; 42(10): 687-692 https://doi.org/10.14348/molcells.2019.0214
Abstract : Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.
Dae Yeon Hwang, Sangkyu Park, Sungbeom Lee, Seung Sik Lee, Takato Imaizumi, and Young Hun SongMol. Cells 2019; 42(10): 693-701 https://doi.org/10.14348/molcells.2019.0199
Abstract : Plants monitor changes in day length to coordinate their flowering time with appropriate seasons. In
Ji Ae Lee, Dong Jin Kim, and Onyou HwangMol. Cells 2019; 42(10): 702-710 https://doi.org/10.14348/molcells.2019.0129
Abstract : Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson’s disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters the brain, exerts neuroprotective effect, and inhibits NF-κB activation. To further assess the utility of KMS99220 as a potential therapeutic agent for PD, we tested whether KMS99220 exerts an anti-inflammatory effect
Dae-Woo Lee, Sang-Kyu Lee, Md Mizanor Rahman, Yu-Jin Kim, Dabing Zhang, and Jong-Seong JeonMol. Cells 2019; 42(10): 711-720 https://doi.org/10.14348/molcells.2019.0109
Abstract : Sink strength optimizes sucrose import, which is fundamental to support developing seed grains and increase crop yields, including those of rice (
Hye-Min Woo, Jin-Moo Lee, Chul-Joong Kim, Jong-Soo Lee, and Yong-Joo JeongMol. Cells 2019; 42(10): 721-728 https://doi.org/10.14348/molcells.2019.0157
Abstract : Non-structural protein 1 (NS1) of influenza virus has been shown to inhibit the innate immune response by blocking the induction of interferon (IFN). In this study, we isolated two single-stranded RNA aptamers specific to NS1 with
Dahwan Lim, Hye Seon Lee, Bonsu Ku, Ho-Chul Shin, and Seung Jun KimMol. Cells 2019; 42(10): 729-738 https://doi.org/10.14348/molcells.2019.0096
Abstract : Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule. The ZZ-type zinc finger (ZZ) domain binds to target proteins and promotes higher-oligomerization of p62. This mechanism is an important step in routing target proteins to the autophagosome. Here, we determined the crystal structure of the PB1 homo-dimer and modeled the p62 PB1 oligomers. These oligomer models were represented by a cylindrical helix and were compared with the previously determined electron microscopic map of a PB1 oligomer. To accurately compare, we mathematically calculated the lead length and radius of the helical oligomers. Our PB1 oligomer model fits the electron microscopy map and is both bendable and stretchable as a flexible helical filament.