Upregulation of Carbonyl Reductase 1 by Nrf2 as a Potential Therapeutic Intervention for Ischemia/ Reperfusion Injury during Liver Transplantation

Jae Hyun Kwon^1,6,7, Jooyoung Lee^2,6,7, Jiye Kim^2,6, Varvara A. Kirchner³, Yong Hwa Jo⁴, Takeshi Miura⁵, Nayoung Kim², Gi-Won Song^1,6, Shin Hwang^1,6, Sung-Gyu Lee^1,6, Young-In Yoon^1,6,*, and Eunyoung Tak^2,6,*

¹Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea, ²Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology; and Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea, ³Division of Transplantation, Department of Surgery and Asan-Minnesota Institute for Innovating Transplantation, University of Minnesota, Minneapolis, MN 55455, USA, ⁴Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Korea, ⁵Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, Osaka 584-8540, Japan, ⁶Asan-Minnesota Institute for Innovating Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea, ⁷These authors contributed equally to this work.