Oleanolic Acids Inhibit Vascular Endothelial Growth Factor Receptor 2 Signaling in Endothelial Cells: Implication for Anti-Angiogenic Therapy

Da-Hye Lee^1,2, Jungsul Lee^3,4, Jongwook Jeon⁵, Kyung-Jin Kim¹, Jang-Hyuk Yun¹, Han-Seok Jeong^1,2, Eun Hui Lee⁶, Young Jun Koh^7,*, and Chung-Hyun Cho^1,2,*

¹Vascular Microenvironment Laboratory, Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 03080, Korea, ²Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea, ³Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea, ⁴Cellex Life Science Inc., Daejeon 34051, Korea, ⁵The Korean Research Institute of Science, Technology and Civilization, Chonbuk National University, Jeonju 54896, Korea, ⁶Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea, ⁷Department of Pathology, College of Korean Medicine, Dongguk University, Goyang 10326, Korea