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Research ArticleOctober 31, 2009
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Characterization of Putative Capsaicin Synthase
Promoter Activity
June-Sik Kim, Minkyu Park, Dong Ju Lee, and Byung-Dong Kim
Mol. Cells 2009; 28(4): 331-339 https://doi.org/10.1007/s10059-009-0128-6
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Sep 30, 2023
Vol.46 No.9, pp. 527~572
COVER PICTURE 
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.
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