Abstract : Targeting fibroblast growth factor receptors (FGFRs) has been slow compared to other targeted cancer therapies for receptor tyrosine kinases, such as epidermal growth factor receptors. The low efficacy and variable response have limited the growth of FGFR inhibitors in clinical use. Nevertheless, recent systematic and genomic approaches have identified the biological conditions for effectively targeting FGFRs and can accelerate the development of targeted drugs. Under clinical and preclinical trials, the inhibitors started fast growing furious races to target FGFRs. Finally, FGFRs will be more actionable and targetable with more precise and effective drugs at the end of the race, passing the finish line.
Young Hyun Jung and Ho Jae Han
Big data-based precision medicine
Daehee Hwang *
Discovery of a distinct senescent cell population in obesity-induced metabolic dysfunction
Gung Lee *
Adipocyte HIFα regulates thermogenic execution.
Ji Seul Han *
A comprehensive atlas of adipose tissue at the single-cell level
Yong Geun Jeon *
RNA signatures from a single blood sampling during pregnancy can detect a pathologic condition before its onset.
Sun-Kyung Lee *
A new study on the relationship between glycogen metabolism and thermogenesis
Seri Choi
What is the origin of N-formylmethionine in eukaryotic cells?
Chang-Seok Lee , Dasom Kim
, and Cheol-Sang Hwang
Circadian autophagy modulates fruit fly lifespan.
Jin Young Huh *
Yuan-Shen Chen, Wei-Chu Chuang, Hsiu-Ni Kung, Ching-Yuan Cheng, Duen-Yi Huang, Ponarulselvam Sekar, and Wan-Wan Lin
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