Molecules and Cells

Cited by CrossRef (42)

  1. Chan-Wang J. Lio, Hiroshi Yuita, Anjana Rao. Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies. 2019;134:1487
    https://doi.org/10.1182/blood.2019791475
  2. Anne Lise Ferrara, Antonietta Liotti, Antonio Pezone, Veronica De Rosa. Therapeutic opportunities to modulate immune tolerance through the metabolism-chromatin axis. Trends in Endocrinology & Metabolism 2022;33:507
    https://doi.org/10.1016/j.tem.2022.04.002
  3. Raghavendra S. Patwardhan, Babita Singh, Debojyoti Pal, Rahul Checker, Mayuri Bandekar, Deepak Sharma, Santosh K. Sandur. Redox regulation of regulatory T-cell differentiation and functions. Free Radical Research 2020;54:947
    https://doi.org/10.1080/10715762.2020.1745202
  4. Ting Wei, Weijie Zhong, Qingshan Li. Role of heterogeneous regulatory T cells in the tumor microenvironment. Pharmacological Research 2020;153:104659
    https://doi.org/10.1016/j.phrs.2020.104659
  5. Ling Lu, Joseph Barbi, Fan Pan. The regulation of immune tolerance by FOXP3. Nat Rev Immunol 2017;17:703
    https://doi.org/10.1038/nri.2017.75
  6. Martin Karl, Christian Sommer, Christian H. Gabriel, Katharina Hecklau, Melanie Venzke, Anna Floriane Hennig, Andreas Radbruch, Matthias Selbach, Ria Baumgrass. Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells. Journal of Molecular Biology 2019;431:3606
    https://doi.org/10.1016/j.jmb.2019.07.031
  7. Lu Tan, Ting Qiu, Rong Xiang, Cheng Cao, Yuqin Deng, Zezhang Tao, Yu Xu. Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis. Life Sciences 2020;241:117101
    https://doi.org/10.1016/j.lfs.2019.117101
  8. He‐Hsiung Cheng, Lin Hung‐Ke, Meei‐Ling Sheu, Chun‐Yi Lee, Yi‐Ching Tsai, De‐Wei Lai. AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression. Immunology 2022
    https://doi.org/10.1111/imm.13600
  9. Kristin Freudenberg, Nadja Lindner, Sebastian Dohnke, Annette I. Garbe, Sonja Schallenberg, Karsten Kretschmer. Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.00125
  10. Matlock A. Jeffries. Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. Clinical Immunology 2018;196:49
    https://doi.org/10.1016/j.clim.2018.02.001
  11. Cheryl Y. Brown, Timothy Sadlon, Christopher M. Hope, Ying Y. Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu, Stephen Pederson, James Breen, Sarah Anne Robertson, Alistair Forrest, Marc Beyer, Simon Charles Barry. Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease. Front. Immunol. 2020;11
    https://doi.org/10.3389/fimmu.2020.01269
  12. Xuejun Xu, Yan Chen, Enyi Liu, Bin Fu, Juan Hua, Xu Chen, Yajing Xu. HMGB1 Recruits TET2/AID/TDG to Induce DNA Demethylation in STAT3 Promoter in CD4+ T Cells from aGVHD Patients. Journal of Immunology Research 2020;2020:1
    https://doi.org/10.1155/2020/7165230
  13. Kyle J. Bednar, Jee Ho Lee, Tatiana Ort. Tregs in Autoimmunity: Insights Into Intrinsic Brake Mechanism Driving Pathogenesis and Immune Homeostasis. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.932485
  14. Rebekah E. Dadey, Creg J. Workman, Dario A. A. Vignali. Tumor Microenvironment. 2022.
    https://doi.org/10.1007/978-3-030-49270-0_6
  15. Beibei Sun, Dongjin Feng, Guangmeng Wang, Xiaohong Yu, Zhongmao Dong, Ling Gao. DL-propargylglycine administration inhibits TET2 and FOXP3 expression and alleviates symptoms of neonatal Cows’ milk allergy in mouse model. Autoimmunity 2020;53:467
    https://doi.org/10.1080/08916934.2020.1836490
  16. Yemei Ma, Ying Ye, Yining Liu, Jing Chen, Yanli Cen, Wenyan Chen, Chun Yu, Qibing Zeng, Aihua Zhang, Guanghong Yang. DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes. 2020;9:519
    https://doi.org/10.1093/toxres/tfaa056
  17. Arimelek Cortés-Hernández, Evelyn Katy Alvarez-Salazar, Saúl Arteaga-Cruz, Katya Rosas-Cortina, Nadyeli Linares, Josefina M. Alberú Gómez, Gloria Soldevila. Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.686530
  18. Luting Yang, Weinan Guo, Shaolong Zhang, Gang Wang. Ubiquitination-proteasome system: A new player in the pathogenesis of psoriasis and clinical implications. Journal of Dermatological Science 2018;89:219
    https://doi.org/10.1016/j.jdermsci.2017.12.002
  19. Shuqiu Chen, Lei Zhang, Yuanlin Ying, Yixuan Wang, Preston R. Arnold, Guangchuan Wang, Junhui Li, R. Mark Ghobrial, Wenhao Chen, Xiang Xiao, Xian C. Li. Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics. American Journal of Transplantation 2020;20:2366
    https://doi.org/10.1111/ajt.15845
  20. Reem Saleh, Salman M. Toor, Rowaida Z. Taha, Dana Al-Ali, Varun Sasidharan Nair, Eyad Elkord. DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen-presenting cells. Epigenetics 2020;15:1275
    https://doi.org/10.1080/15592294.2020.1767373
  21. Ageliki Tsagaratou. TET Proteins in the Spotlight: Emerging Concepts of Epigenetic Regulation in T Cell Biology. 2023;7:106
    https://doi.org/10.4049/immunohorizons.2200067
  22. Qianqian Qiu, Xing Yu, Chencheng Yao, Yujun Hao, Liqing Fan, Chunyi Li, Peng Xu, Geng An, Zheng Li, Zuping He. FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells. Aging 2019;11:12581
    https://doi.org/10.18632/aging.102589
  23. Milagros Silva Morales, Daniel Mueller. Anergy into T regulatory cells: an integration of metabolic cues and epigenetic changes at the Foxp3 conserved non-coding sequence 2. F1000Res 2018;7:1938
    https://doi.org/10.12688/f1000research.16551.1
  24. Nikolas James Tsiouplis, David Wesley Bailey, Lilly Felicia Chiou, Fiona Jane Wissink, Ageliki Tsagaratou. TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease. Front. Cell Dev. Biol. 2021;8
    https://doi.org/10.3389/fcell.2020.623948
  25. Varun Sasidharan Nair, Salman M. Toor, Rowaida Z. Taha, Hibah Shaath, Eyad Elkord. DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. Clin Epigenet 2018;10
    https://doi.org/10.1186/s13148-018-0539-3
  26. Tarmo Äijö, Dimitris Theofilatos, Meng Cheng, Matthew D. Smith, Yue Xiong, Albert S. Baldwin, Ageliki Tsagaratou. TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.940995
  27. Sungkyu Lee, Kyungsoo Park, Jieun Kim, Hyungyu Min, Rho H Seong. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments. EMBO Rep 2018;19
    https://doi.org/10.15252/embr.201845995
  28. Rosa Bacchetta, Kenneth Weinberg. Thymic origins of autoimmunity—lessons from inborn errors of immunity. Semin Immunopathol 2021;43:65
    https://doi.org/10.1007/s00281-020-00835-8
  29. Pramod Darvin, Varun Sasidharan Nair, Eyad Elkord. PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications. Journal of Oncology 2019;2019:1
    https://doi.org/10.1155/2019/3958908
  30. Léonce Kouakanou, Christian Peters, Christine E. Brown, Dieter Kabelitz, Leo D. Wang. Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.765906
  31. Julianna Blagih, Marc Hennequart, Fabio Zani. Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.637960
  32. Varun Sasidharan Nair, Haytham El Salhat, Rowaida Z. Taha, Anne John, Bassam R. Ali, Eyad Elkord. DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. Clin Epigenet 2018;10
    https://doi.org/10.1186/s13148-018-0512-1
  33. Ageliki Tsagaratou. Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation. Immunol. Rev. 2021;300:22
    https://doi.org/10.1111/imr.12940
  34. Ordoñez, Martínez-Calle, Agirre, Prosper. DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters?. Cancers 2019;11:1424
    https://doi.org/10.3390/cancers11101424
  35. Masahiro Okada, Mitsuhiro Kanamori, Kazue Someya, Hiroko Nakatsukasa, Akihiko Yoshimura. Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells. Epigenetics & Chromatin 2017;10
    https://doi.org/10.1186/s13072-017-0129-1
  36. Timothy Sadlon, Cheryl Y Brown, Veronika Bandara, Christopher M Hope, John E Schjenken, Stephen M Pederson, James Breen, Alistair Forrest, Marc Beyer, Sarah Robertson, Simon C Barry. Unravelling the molecular basis for regulatory T-cell plasticity and loss of function in disease. Clin Transl Immunol 2018;7:e1011
    https://doi.org/10.1002/cti2.1011
  37. Vanshika Malviya, Lidia Yshii, Steffie Junius, Abhishek D Garg, Stephanie Humblet‐Baron, Susan M Schlenner. Regulatory T‐cell stability and functional plasticity in health and disease. Immunol Cell Biol 2023;101:112
    https://doi.org/10.1111/imcb.12613
  38. Supinya Iamsawat, Linlu Tian, Anusara Daenthanasanmak, Yongxia Wu, Hung D. Nguyen, David Bastian, Xue-Zhong Yu. Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse. 2019;3:4187
    https://doi.org/10.1182/bloodadvances.2019000531
  39. Christian Peters, Léonce Kouakanou, Dieter Kabelitz. A comparative view on vitamin C effects on αβ- versus γδ T-cell activation and differentiation. 2020;107:1009
    https://doi.org/10.1002/JLB.1MR1219-245R
  40. Eirini Nikolouli, Matthias Hardtke-Wolenski, Martin Hapke, Michael Beckstette, Robert Geffers, Stefan Floess, Elmar Jaeckel, Jochen Huehn. Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance. Front. Immunol. 2017;8
    https://doi.org/10.3389/fimmu.2017.00748
  41. Fuyun Bian, Xiang Ma, Sneha Damal Villivalam, Dongjoo You, Lauren Raquel Choy, Anushka Paladugu, Sarah Fung, Sona Kang. TET2 facilitates PPARγ agonist–mediated gene regulation and insulin sensitization in adipocytes. Metabolism 2018;89:39
    https://doi.org/10.1016/j.metabol.2018.08.006
  42. Marta López-Nevado, Javier Ortiz-Martín, Cristina Serrano, María A. Pérez-Saez, José L. López-Lorenzo, Francisco J. Gil-Etayo, Edgar Rodríguez-Frías, Oscar Cabrera-Marante, Pablo Morales-Pérez, María S. Rodríguez-Pinilla, Rebeca Manso, Rocío N. Salgado-Sánchez, Ana Cerdá-Montagud, Juan F. Quesada-Espinosa, María J. Gómez-Rodríguez, Estela Paz-Artal, Cecilia Muñoz-Calleja, Reyes Arranz-Sáez, Luis M. Allende. Novel Germline TET2 Mutations in Two Unrelated Patients with Autoimmune Lymphoproliferative Syndrome-Like Phenotype and Hematologic Malignancy. J Clin Immunol 2023;43:165
    https://doi.org/10.1007/s10875-022-01361-y