Molecules and Cells

Cited by CrossRef (45)

  1. Wayne Harshbarger, Sudershan Gondi, Scott B. Ficarro, John Hunter, Durga Udayakumar, Deepak Gurbani, William D. Singer, Yan Liu, Lianbo Li, Jarrod A. Marto, Kenneth D. Westover. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. Journal of Biological Chemistry 2017;292:112
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  2. Fiamma Mantovani, Licio Collavin, Giannino Del Sal. Mutant p53 as a guardian of the cancer cell. Cell Death Differ 2019;26:199
    https://doi.org/10.1038/s41418-018-0246-9
  3. Dey Parama, Varsha Rana, Sosmitha Girisa, Elika Verma, Uzini Devi Daimary, Krishan Kumar Thakur, Aviral Kumar, Ajaikumar B. Kunnumakkara. The promising potential of piperlongumine as an emerging therapeutics for cancer. 2021
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  4. Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Kariyappa Vijay, Vallikannan Baskaran, Rangaswamy Lakshminarayana. Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from greens. Food and Chemical Toxicology 2017;106:58
    https://doi.org/10.1016/j.fct.2017.05.024
  5. Jiyan Mohammad, Harsharan Dhillon, Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Megan Orr, John C. Wilkinson, Katie M. Reindl. Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models. Oncotarget 2018;9:10457
    https://doi.org/10.18632/oncotarget.23623
  6. Hui Yang, Bangtao Chen, Zhongfu Zhao, Li Zhang, Yun Zhang, Jie Chen, Xiaoqian Zhang, Xiaohua Zhang, Longfeng Zhao. Heme oxygenase‑1 exerts pro‑apoptotic effects on hepatic stellate cells in�vitro through regulation of nuclear factor‑κB. Exp Ther Med 2018
    https://doi.org/10.3892/etm.2018.6185
  7. Harsharan Dhillon, Sujan Mamidi, Phillip McClean, Katie M. Reindl. Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways. Journal of Medicinal Food 2016;19:578
    https://doi.org/10.1089/jmf.2015.0152
  8. Yuan-Ye Dang, Hua Luo, Yong-Mei Li, Yang Zhou, Xiu Luo, Shui-Mu Lin, Shou-Ping Liu, Simon Ming-Yuen Lee, Chu-Wen Li, Xiao-Yan Dai. Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2. Chin Med 2021;16
    https://doi.org/10.1186/s13020-021-00527-x
  9. Tatiana Takahasi Komoto, Jaehak Lee, Pattawika Lertpatipanpong, Junsun Ryu, Mozart Marins, Ana Lúcia Fachin, Seung Joon Baek. Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer. Toxicol Res. 2021;37:485
    https://doi.org/10.1007/s43188-021-00089-y
  10. Yuki Yamaguchi, Takashi Kasukabe, Shunichi Kumakura. Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis. Int J Oncol 2018
    https://doi.org/10.3892/ijo.2018.4259
  11. Fu Peng, Minru Liao, Rui Qin, Shiou Zhu, Cheng Peng, Leilei Fu, Yi Chen, Bo Han. Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Sig Transduct Target Ther 2022;7
    https://doi.org/10.1038/s41392-022-01110-y
  12. Xinrui Zhang, Mengya Wang, Shanshan Teng, Di Wang, Xin Li, Xiaofeng Wang, Weiwei Liao, Di Wang. Indolyl-chalcone derivatives induce hepatocellular carcinoma cells apoptosis through oxidative stress related mitochondrial pathway in vitro and in vivo. Chemico-Biological Interactions 2018;293:61
    https://doi.org/10.1016/j.cbi.2018.07.025
  13. Fang-Ping Kung, Yun-Ping Lim, Wen-Ying Chao, Yi-Sheng Zhang, Hui-I Yu, Tsai-Sung Tai, Chieh-Hsiang Lu, Shu-Hsin Chen, Yi-Zhen Li, Pei-Wen Zhao, Yu-Pei Yen, Ying-Ray Lee. Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells. Cancers 2021;13:4266
    https://doi.org/10.3390/cancers13174266
  14. Roberta Macrì, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Jessica Maiuolo, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Federica Scarano, Stefano Ruga, Maria Caterina Zito, Lorenza Guarnieri, Ezio Bombardelli, Vincenzo Mollace. Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects. Molecules 2020;25:5768
    https://doi.org/10.3390/molecules25235768
  15. Chutima Talabnin, Krajang Talabnin, Sopit Wongkham. Enhancement of piperlongumine chemosensitivity by silencing heme oxygenase‑1 expression in cholangiocarcinoma cell lines. Oncol Lett 2020;20:2483
    https://doi.org/10.3892/ol.2020.11784
  16. Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali. Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation 2018;2018:1
    https://doi.org/10.1155/2018/4159013
  17. Kamil Lisek, Elena Campaner, Yari Ciani, Dawid Walerych, Giannino Del Sal. Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells. Oncotarget 2018;9:20508
    https://doi.org/10.18632/oncotarget.24974
  18. Jiyan Mohammad, Rahul R. Singh, Cody Riggle, Brandon Haugrud, Maher Y. Abdalla, Katie M. Reindl. JNK inhibition blocks piperlongumine-induced cell death and transcriptional activation of heme oxygenase-1 in pancreatic cancer cells. Apoptosis 2019;24:730
    https://doi.org/10.1007/s10495-019-01553-9
  19. Xiaoke Gu, Jing Chen, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qinghua Song, Jingying Qiu. Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. European Journal of Medicinal Chemistry 2019;180:62
    https://doi.org/10.1016/j.ejmech.2019.07.020
  20. Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada, Ken-ichi Kimura. Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death. J Antibiot 2017;70:429
    https://doi.org/10.1038/ja.2016.99
  21. Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt. P53: A Guardian of Immunity Becomes Its Saboteur through Mutation. IJMS 2020;21:3452
    https://doi.org/10.3390/ijms21103452
  22. Zhengxin Wu, Mengya Zhong, Yu Liu, Yubo Xiong, Zhi Gao, Jingsong Ma, Guohong Zhuang, Xuehui Hong. Application of natural products for inducing ferroptosis in tumor cells. Biotech and App Biochem 2022;69:190
    https://doi.org/10.1002/bab.2096
  23. Shota Uesugi, Yuna Honmura, Mami Nishiyama, Kazuaki Kusakabe, Akio Tonouchi, Tetsuro Yamashita, Masaru Hashimoto, Ken-ichi Kimura. Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors. Bioorganic & Medicinal Chemistry 2019;27:115161
    https://doi.org/10.1016/j.bmc.2019.115161
  24. Dongyup Hahn, Seung Ho Shin, Jong-Sup Bae. Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression. Antioxidants 2020;9:1191
    https://doi.org/10.3390/antiox9121191
  25. Peng Zhu, Jianqiang Qian, Zhongyuan Xu, Chi Meng, Weizhong Zhu, Fansheng Ran, Wei Zhang, Yanan Zhang, Yong Ling. Overview of piperlongumine analogues and their therapeutic potential. European Journal of Medicinal Chemistry 2021;220:113471
    https://doi.org/10.1016/j.ejmech.2021.113471
  26. Mary J. Meegan, Seema Nathwani, Brendan Twamley, Daniela M. Zisterer, Niamh M. O'Boyle. Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents. European Journal of Medicinal Chemistry 2017;125:453
    https://doi.org/10.1016/j.ejmech.2016.09.048
  27. Poorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir. The see-saw of Keap1-Nrf2 pathway in cancer. Critical Reviews in Oncology/Hematology 2017;116:89
    https://doi.org/10.1016/j.critrevonc.2017.02.006
  28. Di Chen, Yangmin Ma, Zhiyu Guo, Li Liu, Yaru Yang, Yuru Wang, Bonan Pan, Luyang Wu, Yuyu Hui, Wenjuan Yang. Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation. Molecules 2020;25:216
    https://doi.org/10.3390/molecules25010216
  29. Maha Sellami, Nicola Luigi Bragazzi. Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention. Nutrients 2020;12:512
    https://doi.org/10.3390/nu12020512
  30. Jie Liang, Jacqueline D. Ziegler, Beate Jahraus, Christian Orlik, Renata Blatnik, Norbert Blank, Beate Niesler, Guido Wabnitz, Thomas Ruppert, Katrin Hübner, Emre Balta, Yvonne Samstag. Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation. Front. Immunol. 2020;11
    https://doi.org/10.3389/fimmu.2020.01172
  31. Xiaoli Cheng, Pan Tian, Wengzhong Zheng, Xuetao Yan. Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression. Cancer Medicine 2020;9:4265
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    https://doi.org/10.18632/oncotarget.10078
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  34. Hye-Yeon Jang, On-Yu Hong, Hyun Jo Youn, Min-Gul Kim, Cheorl-Ho Kim, Sung Hoo Jung, Jong-Suk Kim. 15d-PGJ2 inhibits NF-κB and AP-1-mediated MMP-9 expression and invasion of breast cancer cell by means of a heme oxygenase-1-dependent mechanism. BMB Rep. 2020;53:212
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  35. Sunisa Thongsom, Wipa Suginta, Kyung Jin Lee, Han Choe, Chutima Talabnin. Piperlongumine induces G2/M phase arrest and apoptosis in cholangiocarcinoma cells through the ROS-JNK-ERK signaling pathway. Apoptosis 2017;22:1473
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  36. Chang Hee Jeong, Haram Ryu, Do Hyun Kim, Wei Nee Cheng, Jee Eun Yoon, Sukyung Kang, Sung Gu Han. Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells. Antioxidants 2019;8:553
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  37. Xinhua Lu, Chenyang Xu, Zhexuan Xu, Chunya Lu, Rui Yang, Furui Zhang, Guojun Zhang. Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p/TGFBR1 pathway. BMC Complement Med Ther 2021;21
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  38. Yingying Wang, Jianhui Chang, Xingui Liu, Xuan Zhang, Suping Zhang, Xin Zhang, Daohong Zhou, Guangrong Zheng. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging 2016;8:2915
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