Molecules and Cells

Cited by CrossRef (45)

  1. Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Seok-Won Jung, Ho-Kyoung Kim, Seung-Yeol Nah. Plant Lysophosphatidic Acids: A Rich Source for Bioactive Lysophosphatidic Acids and Their Pharmacological Applications. Biological & Pharmaceutical Bulletin 2016;39:156
    https://doi.org/10.1248/bpb.b15-00575
  2. Kippeum Lee, Heegu Jin, Sungwoo Chei, Hyun-Ji Oh, Sun-Hye Choi, Seung-Yeol Nah, Boo-Yong Lee. The Gintonin-Enriched Fraction of Ginseng Regulates Lipid Metabolism and Browning via the cAMP-Protein Kinase a Signaling Pathway in Mice White Adipocytes. Biomolecules 2020;10:1048
    https://doi.org/10.3390/biom10071048
  3. Hyeon-Joong Kim, Seok-Won Jung, Seog-Young Kim, Ik-Hyun Cho, Hyoung-Chun Kim, Hyewhon Rhim, Manho Kim, Seung-Yeol Nah. Panax ginseng as an adjuvant treatment for Alzheimer's disease. Journal of Ginseng Research 2018;42:401
    https://doi.org/10.1016/j.jgr.2017.12.008
  4. Sun-Hye Choi, Rami Lee, Sung Min Nam, Do-Geun Kim, Ik-Hyun Cho, Hyoung-Chun Kim, Yoonjeong Cho, Hyewhon Rhim, Seung-Yeol Nah. Ginseng gintonin, aging societies, and geriatric brain diseases. Integrative Medicine Research 2021;10:100450
    https://doi.org/10.1016/j.imr.2020.100450
  5. Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua Du. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules 2017;22:410
    https://doi.org/10.3390/molecules22030410
  6. Muhammad Ikram, Rahat Ullah, Amjad Khan, Myeong Ok Kim. Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders. Cells 2020;9:1464
    https://doi.org/10.3390/cells9061464
  7. Md. Ataur Rahman, Hongik Hwang, Seung-Yeol Nah, Hyewhon Rhim. Gintonin stimulates autophagic flux in primary cortical astrocytes. Journal of Ginseng Research 2020;44:67
    https://doi.org/10.1016/j.jgr.2018.08.004
  8. Ralph M. Trüeb. Nutrition for Healthy Hair. 2020.
    https://doi.org/10.1007/978-3-030-59920-1_6
  9. Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil’eva, Andrey V. Maltsev, Pavel N. Shevtsov, Alexander V. Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov. Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity. Sci Rep 2022;12
    https://doi.org/10.1038/s41598-022-16817-9
  10. Rami Lee, Na-Eun Lee, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Sung-Hee Hwang, Seung-Yeol Nah. Effects of gintonin-enriched fraction on hippocampal gene expressions. Integrative Medicine Research 2021;10:100475
    https://doi.org/10.1016/j.imr.2020.100475
  11. Md. Jakaria, Shofiul Azam, Eun-Ae Go, Md. Sahab Uddin, Song-Hee Jo, Dong-Kug Choi. Biological evidence of gintonin efficacy in memory disorders. Pharmacological Research 2021;163:105221
    https://doi.org/10.1016/j.phrs.2020.105221
  12. Zhiyong Wang, Zhen Zhang, Jiangang Liu, Mingdong Guo, Hao Li. Panax Ginseng in the treatment of Alzheimer's disease and vascular dementia. Journal of Ginseng Research 2023;47:506
    https://doi.org/10.1016/j.jgr.2023.03.001
  13. Hee-Jung Cho, Sun-Hye Choi, Hyeon-Joong Kim, Byung-Hwan Lee, Hyewon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah. Bioactive lipids in gintonin-enriched fraction from ginseng. Journal of Ginseng Research 2019;43:209
    https://doi.org/10.1016/j.jgr.2017.11.006
  14. Eun-Joo Shin, Yoon Hee Chung, Naveen Sharma, Bao Trong Nguyen, Sung Hoon Lee, Sang Won Kang, Seung-Yeol Nah, Myung Bok Wie, Toshitaka Nabeshima, Ji Hoon Jeong, Hyoung-Chun Kim. Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector. Neurochem Res 2020;45:2991
    https://doi.org/10.1007/s11064-020-03147-3
  15. Adeleh Sahebnasagh, Samira Eghbali, Fatemeh Saghafi, Antoni Sureda, Razieh Avan. Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases. Immun Ageing 2022;19
    https://doi.org/10.1186/s12979-022-00292-x
  16. Min Gi Jo, Muhammad Ikram, Myeung Hoon Jo, Lang Yoo, Kwang Chul Chung, Seung-Yeol Nah, Hongik Hwang, Hyewhon Rhim, Myeong Ok Kim. Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway. Mol Neurobiol 2019;56:39
    https://doi.org/10.1007/s12035-018-1020-1
  17. Md. Jakaria, Md. Ezazul Haque, Joonsoo Kim, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi. Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study. Oncotarget 2018;9:33601
    https://doi.org/10.18632/oncotarget.26035
  18. Mohammad Amine Reslan, Hawraa Issa, Nadine Al-Haj, Stanley Ibeh, Yara Yehya, Houssein Hajj Hassan, Firas Kobeissy, Ali H. Eid, Kazem Zibara, Abdullah Shaito. Role of Micronutrients in Brain Health. 2018.
    https://doi.org/10.1007/978-981-16-6467-0_15
  19. The-Vinh Tran, Eun-Joo Shin, Lan Thuy Ty Nguyen, Youngho Lee, Dae-Joong Kim, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Kazuya Toriumi, Toshitaka Nabeshima, Kiyofumi Yamada, Hyoung-Chun Kim. Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Mol Neurobiol 2017
    https://doi.org/10.1007/s12035-017-0638-8
  20. Muhammad Ikram, Min Gi Jo, Tae Ju Park, Min Woo Kim, Ibrahim Khan, Myeung Hoon Jo, Myeong Ok Kim, Yueliang Zhao. Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects. Oxidative Medicine and Cellular Longevity 2021;2021:1
    https://doi.org/10.1155/2021/6635552
  21. Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah. Gintonin absorption in intestinal model systems. Journal of Ginseng Research 2018;42:35
    https://doi.org/10.1016/j.jgr.2016.12.007
  22. Ying Wang, Zhu Zhou, Hua Tan, Shenghua Zhu, Yiran Wang, Yingxia Sun, Xin-Min Li, Jun-Feng Wang, Wolff Kirsch. Nitrosylation of Vesicular Transporters in Brain of Amyloid Precursor Protein/Presenilin 1 Double Transgenic Mice. JAD 2016;55:1683
    https://doi.org/10.3233/JAD-160700
  23. Ji-Hun Kim, Ra Mi Lee, Hyo-Bin Oh, Tae-Young Kim, Hyewon Rhim, Yoon Kyung Choi, Jong-Hoon Kim, Seikwan Oh, Do-Geun Kim, Ik-Hyun Cho, Seung-Yeol Nah. Atypical formations of gintonin lysophosphatidic acids as new materials and their beneficial effects on degenerative diseases. Journal of Ginseng Research 2023
    https://doi.org/10.1016/j.jgr.2023.02.004
  24. Bao Trong Nguyen, Eun-Joo Shin, Ji Hoon Jeong, Naveen Sharma, Ngoc Kim Cuong Tran, Yen Nhi Doan Nguyen, Dae-Joong Kim, Myung Bok Wie, Yi Lee, Jae Kyung Byun, Sung Kwon Ko, Seung-Yeol Nah, Hyoung-Chun Kim. Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway. Journal of Ginseng Research 2023;47:561
    https://doi.org/10.1016/j.jgr.2023.01.005
  25. Ogbodo Onyebuchi John, Ihim Stella Amarachi, Agbo Precious Chinazom, Echezona Adaeze, Mayur B. Kale, Mohit D. Umare, Aman B. Upaganlawar. Phytotherapy: A promising approach for the treatment of Alzheimer's disease. Pharmacological Research - Modern Chinese Medicine 2022;2:100030
    https://doi.org/10.1016/j.prmcm.2021.100030
  26. Eliezer Joseph, Daniel Miguel Ángel Villalobos-Acosta, Mónica Adriana Torres-Ramos, Eunice Dalet Farfán-García, Modesto Gómez-López, Ángel Miliar-García, Manuel Jonathan Fragoso-Vázquez, Iohanan Daniel García-Marín, José Correa-Basurto, Martha Cecilia Rosales-Hernández. Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer’s Disease Model. J Mol Neurosci 2020;70:180
    https://doi.org/10.1007/s12031-019-01426-5
  27. Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Seung-Yeol Nah, Hyog Young Kwon. Amelioration of muscle wasting by gintonin in cancer cachexia. Neoplasia 2021;23:1307
    https://doi.org/10.1016/j.neo.2021.11.008
  28. Jing Li, Qingxia Huang, Jinjin Chen, Hongyu Qi, Jiaqi Liu, Zhaoqiang Chen, Daqing Zhao, Zeyu Wang, Xiangyan Li. Neuroprotective Potentials of Panax Ginseng Against Alzheimer’s Disease: A Review of Preclinical and Clinical Evidences. Front. Pharmacol. 2021;12
    https://doi.org/10.3389/fphar.2021.688490
  29. Sun-Hye Choi, Seok-Won Jung, Byung-Hwan Lee, Hyeon-Joong Kim, Sung-Hee Hwang, Ho-Kyoung Kim, Seung-Yeol Nah. Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions. Front. Pharmacol. 2015;6
    https://doi.org/10.3389/fphar.2015.00245
  30. Edward J. Calabrese. Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects. Molecules 2020;25:2719
    https://doi.org/10.3390/molecules25112719
  31. Rami Lee, Byung-Hwan Lee, Sun-Hye Choi, Yeon-Jin Cho, Han-Sung Cho, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Man Hee Rhee, Seung-Yeol Nah. Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes. Journal of Ginseng Research 2021;45:583
    https://doi.org/10.1016/j.jgr.2021.02.006
  32. Rami Lee, Han Sang Lee, Won-Woo Kim, Manho Kim, Seung-Yeol Nah. Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participant-blinded placebo-controlled study. Journal of Ginseng Research 2023;47:735
    https://doi.org/10.1016/j.jgr.2023.06.005
  33. Do-Geun Kim, Minhee Jang, Sun-Hye Choi, Hyeon-Joong Kim, Hyunjhung Jhun, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Seung-Yeol Nah. Gintonin, a ginseng-derived exogenous lysophosphatidic acid receptor ligand, enhances blood-brain barrier permeability and brain delivery. International Journal of Biological Macromolecules 2018;114:1325
    https://doi.org/10.1016/j.ijbiomac.2018.03.158
  34. Woo-Jin Lee, Yong-Won Shin, Hyeyeon Chang, Hye-Rim Shin, Won-Woo Kim, Seok-Won Jung, Manho Kim, Seung-Yeol Nah. Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial. Integrative Medicine Research 2022;11:100773
    https://doi.org/10.1016/j.imr.2021.100773
  35. Tanu Bisht, Sonali Sundram, Rishabha Malviya, Akanksha Pandey. Herbal Components for the Treatment of Alzheimer's Disease. NPJ 2023;13
    https://doi.org/10.2174/2210315513666230123111541
  36. Jangsup Moon, Sun-Hye Choi, Ji-Young Shim, Hyun-Jung Park, Min-Jung Oh, Manho Kim, Seung-Yeol Nah. Gintonin Administration is Safe and Potentially Beneficial in Cognitively Impaired Elderly. 2018;32:85
    https://doi.org/10.1097/WAD.0000000000000213
  37. Woo-Jin Lee, Yong-Won Shin, Hyeyeon Chang, Hye-Rim Shin, Won-Woo Kim, Seok-Won Jung, Seung-Hong Choi, Manho Kim, Seung-Yeol Nah. Cognitive improvement effect of gintonin might be associated with blood-brain barrier permeability enhancement: dynamic contrast-enhanced MRI pilot study. Transl Clin Pharmacol 2021;29:21
    https://doi.org/10.12793/tcp.2021.29.e2
  38. Sindhu Ramesh, Manoj Govindarajulu, Shriya Patel, Rishi M. Nadar, Mary Fabbrini, Randall C. Clark, Jack Deruiter, Timothy Moore, Dinesh Chandra Agrawal, Muralikrishnan Dhanasekaran. Medicinal Herbs and Fungi. 2021.
    https://doi.org/10.1007/978-981-33-4141-8_4
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  41. Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh. Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice. Journal of Ginseng Research 2021;45:510
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  42. Laura Sánchez-Marín, David Ladrón de Guevara-Miranda, M. Carmen Mañas-Padilla, Francisco Alén, Román D. Moreno-Fernández, Caridad Díaz-Navarro, José Pérez-del Palacio, María García-Fernández, Carmen Pedraza, Francisco J. Pavón, Fernando Rodríguez de Fonseca, Luis J. Santín, Antonia Serrano, Estela Castilla-Ortega. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology 2018;133:189
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  43. Eun-Joo Shin, Sung Hoon Lee, Naveen Sharma, Bao Trong Nguyen, Yoon Hee Chung, Sang Won Kang, Seung-Yeol Nah, Yu Jeung Lee, Toshitaka Nabeshima, Ji Hoon Jeong, Hyoung-Chun Kim. An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling. Free Radical Research 2021;55:11
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  44. Rami Lee, Sun-Hye Choi, Han-Sung Cho, Hongik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release. Molecules 2021;26:6298
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